List of Relevant StemoniX® Research and Marketing Documents
High-throughput screening of microBrain® 3D.In a collaborative study between StemoniX and Janssen, the microBrain 3D platform was used to screen the LOPAC®1280library identifying 111 compounds that modulated the neural network. “[T]hese data demonstrate the suitability and utility of human iPSC-derived neurospheroids as a screening platform for CNS-based drug discovery.”
Creation of a custom disease model.CDKL5 Deficiency Disorder (CDD) is a genetic neurodevelopmental disorder resulting in seizure, developmental delay, and severe cognitive disability. In this collaborative study with UCSD, StemoniX scientists created a custom microBrain 3D platform using cells from a CDD patient to study compounds that rescued the CDD neural phenotype in high-throughput.
Neurodevelopmental toxicity.Brain development occurs early in gestation, and the developing brain is more susceptible to chemical onslaught than the mature brain. In this study, StemoniX scientists mimicked brain development using custom microBrain 2D and 3D platforms to study safe treatments for viral diseases.
Neuronal communication. Two hallmarks of neurodegenerative diseases are dendritic damage and synapse loss. To study the interactions between human neurons, scientists at the University of Minnesota used microBrain 2D to develop a fluorescent imaging method that can be used to identify disease and drug-induced synaptic changes.
Viral infection assay. The accuracy of both the in vivo characteristics and cellular properties of the microBrain 2D platform led scientists at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) to use microBrain 2D study neurotropic viral infectivity and mechanisms to block these viruses.